{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00299 is a long intergenic noncoding RNA that has emerged as a multifunctional regulator in human biology and disease. Its disruption has been linked to neurodevelopmental abnormalities, with evidence suggesting that LINC00299 is abundantly expressed in the brain and required for proper neural development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, epigenome‐wide studies have identified hypermethylation at the LINC00299 locus in peripheral blood samples of triple‐negative breast cancer patients, indicating that alterations in its methylation status may serve as a circulating biomarker for the disease, particularly in younger women."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, functional studies in atherosclerosis models have demonstrated that LINC00299 can act as a molecular “sponge” for microRNAs—such as miR-490-3p and miR-135a-5p—to modulate key downstream targets (including AURKA and XBP1), thereby promoting vascular smooth muscle and endothelial cell proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, expression network analyses in hypertrophic scars suggest that LINC00299 is associated with metastasis-related genes (for example, INHBA, SMAD7, COL1A1, TGFβ3, and MYC), hinting at further roles in the regulation of cell proliferation and differentiation in pathological contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael E Talkowski, Gilles Maussion, Liam Crapper, et al. 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