{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00301 is a long noncoding RNA with multifaceted roles in disease pathogenesis and diagnosis. In non‐small cell lung cancer, LINC00301 is highly expressed and functions as an oncogene by promoting cellular proliferation, facilitating cell cycle progression, enhancing migration and invasion, and suppressing apoptosis. It also contributes to an immunosuppressive microenvironment by increasing regulatory T cells while reducing CD8⁺ T cells, and mechanistic studies reveal that it acts via FOXC1‐dependent transcriptional regulation, interacting with EZH2 and affecting downstream effectors such as HIF1α."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, integrated data‐mining approaches in brain tumor datasets have identified LINC00301 as part of a lncRNA signature that discriminates cancerous from normal tissues, suggesting a broader role in tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Analysis of competing endogenous RNA networks in osteonecrosis of the femoral head further designates LINC00301 as a highly connected node potentially involved in the regulation of skeletal development‐related processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, LINC00301 has been incorporated into a panel of testis‐specific extracellular vesicle lncRNAs, which has demonstrated high sensitivity and specificity for predicting the presence of testicular spermatozoa in nonobstructive azoospermia. This finding highlights its promise as a noninvasive biomarker with potential clinical utility in male infertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifaceted roles of LINC00301 in promoting tumorigenesis, modulating immune responses, and serving as a potential diagnostic indicator across diverse pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cheng-Cao Sun, Wei Zhu, Shu-Jun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13073-020-00773-y"}], "href": "https://doi.org/10.1186/s13073-020-00773-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32878637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32878637"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Paolo Cremaschi, Roberta Carriero, Stefania Astrologo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Association Rule Mining Approach to Discover lncRNAs Expression Patterns in Cancer Datasets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/146250"}], "href": "https://doi.org/10.1155/2015/146250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26273587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26273587"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ning Han, Zengchun Li "}, {"type": "b", "children": [{"type": "t", "text": "Non-coding RNA Identification in Osteonecrosis of the Femoral Head Using Competitive Endogenous RNA Network Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Orthop Surg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/os.12834"}], "href": "https://doi.org/10.1111/os.12834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33749138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33749138"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yun Xie, Jiahui Yao, Xinzong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A panel of extracellular vesicle long noncoding RNAs in seminal plasma for predicting testicular spermatozoa in nonobstructive azoospermia patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/deaa184"}], "href": "https://doi.org/10.1093/humrep/deaa184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32914196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32914196"}]}]}]}