| Name | long intergenic non-protein coding RNA 304 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00304 is a long noncoding RNA implicated in several disease processes through its regulation of cell cycle and proliferation, as well as through epigenetic modifications. In prostate cancer, LINC00304 is upregulated and functions as a downstream effector of androgen receptor signaling. Its overexpression promotes cancer cell proliferation and cell cycle progression, in part by enhancing CCNA1 expression, suggesting that it may serve as a promising diagnostic and therapeutic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of cardiac biology, differential expression of LINC00304 between fetal and adult hearts indicates its potential involvement in modulating cardiac cell proliferation during the transition from fetal to adult life."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in rheumatoid arthritis, aberrant expression of LINC00304 in peripheral blood mononuclear cells correlates with clinical parameters such as disease course and joint tenderness, highlighting its utility as a potential biomarker for disease occurrence and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Lastly, altered methylation patterns of LINC00304 in obese individuals, independent of age, point to its possible role as an epigenetic marker linking obesity to age-related molecular changes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pu Zhang, Yali Lu, Zhe Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Androgen-responsive lncRNA LINC00304 promotes cell cycle and proliferation via regulating CCNA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.23811"}], "href": "https://doi.org/10.1002/pros.23811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31012142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31012142"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jue Wang, Zhimin Geng, Jiakan Weng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microarray analysis reveals a potential role of LncRNAs expression in cardiac cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Dev Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12861-016-0139-4"}], "href": "https://doi.org/10.1186/s12861-016-0139-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27863467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27863467"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Long, Jian Liu, Hui Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Network analysis and transcriptome profiling in peripheral blood mononuclear cells of patients with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2020.9601"}], "href": "https://doi.org/10.3892/etm.2020.9601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33456537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33456537"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Markus Sällman Almén, Emil K Nilsson, Josefin A Jacobsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2014.07.009"}], "href": "https://doi.org/10.1016/j.gene.2014.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25010727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25010727"}]}]}]}
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| Synonyms | NCRNA00304, C16ORF81 |
| Proteins | CP081_HUMAN |
| NCBI Gene ID | 283860 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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LINC00304 has 1,276 functional associations with biological entities spanning 6 categories (molecular profile, organism, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 25 datasets.
Click the + buttons to view associations for LINC00304 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of LINC00304 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of LINC00304 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of LINC00304 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00304 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of LINC00304 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with LINC00304 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00304 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of LINC00304 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00304 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at LINC00304 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00304 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of LINC00304 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of LINC00304 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of LINC00304 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of LINC00304 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of LINC00304 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of LINC00304 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of LINC00304 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of LINC00304 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00304 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain LINC00304 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting LINC00304 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of LINC00304 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at LINC00304 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of LINC00304 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
