{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00305 is a long intergenic noncoding RNA with emerging roles in the regulation of vascular inflammation and immune responses. Studies have shown that its expression is enriched in atherosclerotic plaques and monocytes, and overexpression of LINC00305 drives the production of pro‐inflammatory cytokines through activation of nuclear factor‐κB (NF-κB). Mechanistically, LINC00305 interacts with the lipocalin-1 interacting membrane receptor (LIMR) to enhance the association with the aryl-hydrocarbon receptor repressor (AHRR), promoting AHRR expression and nuclear localization that, in turn, facilitates NF-κB activation and downstream inflammatory gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In immune-mediated disorders, elevated LINC00305 levels have been observed in rheumatoid arthritis patients, where its expression correlates positively with disease activity indices and established inflammatory markers, suggesting a potential biomarker role in disease diagnosis and management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Conversely, alterations in LINC00305 expression have also been documented in multiple sclerosis, further underscoring its involvement in modulating immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, nutritional interventions aimed at reducing inflammation—for instance, dietary supplementation with polyphenols and methylsulfonylmethane in endurance athletes—have been associated with increased levels of LINC00305 along with other inflammatory RNA biomarkers, suggesting that LINC00305 is responsive to systemic inflammatory cues and may serve as a marker of muscle recovery and injury in such contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, in vascular endothelial cells, hypoxic stress up-regulates LINC00305, which functions as a molecular sponge for miR-136 and thereby promotes cell apoptosis. This finding indicates that LINC00305 contributes to endothelial dysfunction by modulating microRNA activity under stress conditions, providing further insight into its role in vascular pathophysiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies suggest that LINC00305 is a multifaceted regulator that promotes inflammatory responses through NF-κB signaling, influences vascular smooth muscle cell phenotype, and modulates endothelial cell survival, thereby positioning it as a potential biomarker and therapeutic target in a range of cardiovascular and immune-mediated diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dan-Dan Zhang, Wen-Tian Wang, Jian Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-κB pathway in human monocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep46204"}], "href": "https://doi.org/10.1038/srep46204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28393844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28393844"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "A S Wahba, M E Ibrahim, N M Mesbah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum LINC00305 expression and its genetic variant rs2850711 are associated with clinical and laboratory features of rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Biomed Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09674845.2020.1744942"}], "href": "https://doi.org/10.1080/09674845.2020.1744942"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32188348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32188348"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elizabeth A Tanner, Melody A Gary, Asheal A Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alterations in Systemic Inflammatory Response Following a Half-Marathon Race with a Combined Curcumin and Pomegranate Supplement: A Feasibility Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Diet Suppl (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/19390211.2020.1786206"}], "href": "https://doi.org/10.1080/19390211.2020.1786206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32657201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32657201"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elizabeth A Tanner, Melody A Gary, Stephan Michalik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Optimized Curcumin, Pomegranate Extract, and Methylsulfonylmethane Reduce Acute, Systemic Inflammatory Response to a Half-marathon Race."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Altern Ther Health Med (2022)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32619204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32619204"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bo-Ya Zhang, Zhe Jin, Zhuo Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic noncoding RNA 00305 sponges miR-136 to regulate the hypoxia induced apoptosis of vascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.07.099"}], "href": "https://doi.org/10.1016/j.biopha.2017.07.099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28763747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28763747"}]}]}]}