LINC00308 Gene

Name long intergenic non-protein coding RNA 308
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Among the studies provided, only one explicitly evaluates LINC00308. In a comprehensive analysis of prostate cancer transcriptomes, LINC00308 was identified as one of three lncRNAs within a ceRNA (competing endogenous RNA) network that showed significant association with overall patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the precise mechanistic details were not fully delineated, the differential expression and survival association of LINC00308 suggest that it may function as a regulatory RNA molecule that sequesters specific microRNAs, thereby modulating the expression of downstream mRNAs involved in tumor progression. This ceRNA activity positions LINC00308 as a potential prognostic biomarker and even a therapeutic target in prostate cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Jiang, Junjie Guo, Zhongchun Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Potential Prostate Cancer-Related Pseudogenes Based on Competitive Endogenous RNA Network Hypothesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.910886"}], "href": "https://doi.org/10.12659/MSM.910886"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29923546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29923546"}]}]}]}
Synonyms PRED16, NCRNA00308, C21ORF74
Proteins CU074_HUMAN
NCBI Gene ID 54143
API
Download Associations
Predicted Functions View LINC00308's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00308's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00308's ARCHS4 Predicted Functions.

Functional Associations

LINC00308 has 320 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for LINC00308 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of LINC00308 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00308 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00308 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00308 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of LINC00308 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00308 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00308 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00308 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of LINC00308 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00308 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00308 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00308 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of LINC00308 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00308 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain LINC00308 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00308 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00308 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.