{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Deregulation of the long non‐coding RNA LINC00310 has emerged from multiple studies as a potential oncogenic driver and prognostic biomarker in diverse clinical settings. In breast cancer, LINC00310 expression increases with disease progression and poor patient survival, and functional experiments using CRISPR/Cas9 knockout and rescue approaches have demonstrated that LINC00310 promotes cell proliferation and in vivo tumor growth by up‐regulating the c-Myc pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LINC00310 is part of a gene signature associated with recurrence in breast invasive carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "as well as being linked with recurrence in papillary thyroid cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similar oncogenic functions appear in other tumor types; for example, during the malignant transformation of human bronchial epithelial cells exposed to glycidyl methacrylate, LINC00310 is up‐regulated in later stages along with its target gene C-Myc."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Furthermore, in buccal mucosa squamous cell carcinoma, LINC00310 exhibits marked expression alterations and is associated with poorer clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Beyond its role in cancer, genome‐wide association analyses have identified LINC00310 as a candidate gene expressed in arterial tissues and linked to the risk of spontaneous coronary artery dissection"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while integrative ceRNA network studies in Duchenne muscular dystrophy have uncovered LINC00310 as a hub potentially contributing to the increased tumorigenesis observed in this condition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that LINC00310 functions as an oncogenic lncRNA by modulating key regulatory pathways—most notably via c-Myc—and that its aberrant expression is closely associated with tumor recurrence, progression, and adverse clinical outcomes. Accordingly, LINC00310 holds promise not only as a prognostic marker in various cancers but also as a potential target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Juan Li, Wanxin Peng, Lutao Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The oncogenic potentials and diagnostic significance of long non-coding RNA LINC00310 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13750"}], "href": "https://doi.org/10.1111/jcmm.13750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29993199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29993199"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hairong Liu, Juan Li, Pratirodh Koirala, et al. 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