| HGNC Family | Non-coding RNAs |
| Name | long intergenic non-protein coding RNA 312 |
| Description | This gene produces an intronless transcript that is thought to function as a tumor suppressor. This transcript is downregulated in nasopharyngeal carcinoma and is a negative regulator of estrogen receptor signaling. A common polymorphism in this transcript allows the production of a 94 aa open reading frame in some individuals, which may interact directly with estrogen receptor 1 (PMID:15474036). This open reading frame does not exist on the reference genome haplotype, which is hypothesized to function through a non-coding RNA product. [provided by RefSeq, Mar 2017] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00312 is a long non‐coding RNA that exhibits context‐dependent functions in tumorigenesis and other pathological processes. In lung adenocarcinoma, LINC00312 has been reported to promote tumor progression by enhancing migration, invasion, and vasculogenic mimicry through its direct interaction with the transcription factor YBX1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and is similarly implicated in promoting myofibroblast transdifferentiation in oral submucous fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In contrast, studies in non‐small cell lung cancer, colorectal cancer, bladder cancer, breast cancer, and ovarian cancer show that LINC00312 is down‐regulated in tumor tissues and functions as a tumor suppressor by inhibiting cell proliferation, migration, and invasion while promoting apoptosis and chemosensitivity. These tumor‐suppressive effects are mediated partly via modulation of microRNA-dependent pathways such as the miR‑21–PTEN axis, the miR‑9–cadherin‑1 (CDH1) axis, and via regulation of miR‑197‑3p and matrix metalloproteinases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": " Moreover, genetic polymorphisms in LINC00312 have been associated with nasopharyngeal carcinoma risk and prognosis, underscoring its potential utility as a diagnostic and prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Emerging evidence additionally suggests that LINC00312 may be involved in non-malignant conditions such as type 2 diabetes via interactions with ferritin‐related genetic variants."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these findings highlight the multifaceted and context‐dependent roles of LINC00312, suggesting that its biological functions vary according to tissue type and disease state while providing a promising basis for the development of novel diagnostic and therapeutic strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhenzi Peng, Jun Wang, Bin Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0920-z"}], "href": "https://doi.org/10.1186/s12943-018-0920-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30470227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30470227"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chuan-Hang Yu, Chih-Yuan Fang, Cheng-Chia Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00312/YBX1 Axis Regulates Myofibroblast Activities in Oral Submucous Fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21082979"}], "href": "https://doi.org/10.3390/ijms21082979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32340273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32340273"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qingqing Zhu, Tangfeng Lv, Ying Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13142"}], "href": "https://doi.org/10.1111/jcmm.13142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28338293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28338293"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yun-Yan Wang, Zi-Yu Wu, Gong-Cheng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-5303-8"}], "href": "https://doi.org/10.1007/s13277-016-5303-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27631965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27631965"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gang Li, Changming Wang, Yongbing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00312 represses proliferation and metastasis of colorectal cancer cells by regulation of miR-21."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13830"}], "href": "https://doi.org/10.1111/jcmm.13830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30134003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30134003"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yajun Chen, Fanghua Qiu, Lichan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA LINC00312 regulates breast cancer progression through the miR‑9/CDH1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10895"}], "href": "https://doi.org/10.3892/mmr.2019.10895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31894332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31894332"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chuanqi Zhang, Min Wang, Cong Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA Linc00312 modulates the sensitivity of ovarian cancer to cisplatin via the Bcl-2/Caspase-3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Trends (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5582/bst.2018.01052"}], "href": "https://doi.org/10.5582/bst.2018.01052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29952351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29952351"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zhen Guo, Mei-Hua Bao, Yun-Xia Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Polymorphisms of Long Non-coding RNA Linc00312 Are Associated With Susceptibility and Predict Poor Survival of Nasopharyngeal Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.698558"}], "href": "https://doi.org/10.3389/fcell.2021.698558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34336850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34336850"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jihye Kim, Hye Won Woo, Min-Ho Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide gene and serum ferritin interaction in the development of type 2 diabetes in adults aged 40 years or older."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nutr Metab Cardiovasc Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.numecd.2021.09.028"}], "href": "https://doi.org/10.1016/j.numecd.2021.09.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34916119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34916119"}]}]}]}
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| Synonyms | ERR-10, NAG7, LOH3CR2A, NAG-7, ERR10, NCRNA00312, LMCD1DN |
| Proteins | L3R2A_HUMAN |
| NCBI Gene ID | 29931 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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LINC00312 has 919 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 33 datasets.
Click the + buttons to view associations for LINC00312 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of LINC00312 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of LINC00312 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of LINC00312 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of LINC00312 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of LINC00312 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00312 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of LINC00312 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00312 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of LINC00312 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of LINC00312 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00312 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with LINC00312 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at LINC00312 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00312 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of LINC00312 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of LINC00312 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with LINC00312 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing LINC00312 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of LINC00312 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of LINC00312 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of LINC00312 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of LINC00312 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of LINC00312 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of LINC00312 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for LINC00312 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of LINC00312 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00312 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain LINC00312 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of LINC00312 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of LINC00312 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for LINC00312 from the Pathway Commons Protein-Protein Interactions dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at LINC00312 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of LINC00312 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
