{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00313 is an emerging long non‐coding RNA with oncogenic functions that has been reported to be aberrantly up‐regulated in a variety of human malignancies and pathologic conditions. In glioblastoma, papillary thyroid cancer, osteosarcoma, non‐small cell lung cancer, cervical cancer, and early‐stage lung cancer, overexpression of LINC00313 promotes tumor progression by enhancing cell proliferation, migration, invasion, epithelial–mesenchymal transition, and by inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": " In several studies, mechanistic investigations revealed that LINC00313 exerts its oncogenic role by acting as a competing endogenous RNA, “sponging” tumor‐suppressive microRNAs – for instance, miR‑342‑3p, miR‑485‑5p, miR‑4429, miR‑422a, and miR‑4677‑3p – thereby relieving repression on downstream targets such as Zic4, FOSL2, CDK6, or by regulating epigenetic modifiers (for example, recruiting DNMT1 and DNMT3B to enhance promoter methylation of target genes such as ALX4) to activate oncogenic signaling pathways including AKT/mTOR."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in classical tumorigenesis, LINC00313 has been implicated in viral‐related pathologies. During Kaposi’s sarcoma‐associated herpesvirus reactivation, LINC00313 is up‐regulated and interacts with the HIV‑1 secreted Tat protein, which disrupts its association with epigenetic regulatory complexes (such as PRC2) and, in turn, modulates endothelial cell motility and angiogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, beyond its implication in cancer, LINC00313 has been identified as a hub long non‐coding RNA in osteoarthritis, where it may regulate extracellular matrix organization and chondrocyte homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, the accumulated evidence suggests that LINC00313 acts as a multifunctional regulator in disease, serving not only as a potential diagnostic and prognostic biomarker but also as a promising therapeutic target in various oncologic and non‐oncologic conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lianqi Shao, Qianru He, Yunhui Liu, et al. 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