{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00319 is a long noncoding RNA that is recurrently upregulated across a wide spectrum of human cancers and even in ischemic stroke, acting predominantly as an oncogenic regulator by functioning as a competing endogenous RNA. In ovarian cancer, for instance, LINC00319 promotes cell proliferation, migration, and invasion by sponging miR‐423‑5p to upregulate NACC1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In lung adenocarcinoma and lung cancer, its elevated expression is linked with poor patient prognosis, with studies demonstrating that LINC00319 accelerates tumor growth by modulating the miR‑450b‑5p/EZH2 pathway as well as by directly binding miR‑32, leading to increased expression of oncogenic targets such as AURKA, SOX9, and TWIST1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In oral squamous cell carcinoma, LINC00319 enhances malignant behaviors by sequestering miR‑199a‑5p and consequently upregulating FZD4."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in nasopharyngeal carcinoma, it facilitates tumor progression via the miR‑1207‑5p/KLF12 axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in acute myeloid leukemia it is transcriptionally activated by MYC and further promotes leukemogenesis through an FUS‑dependent regulation of SIRT6."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In bladder cancer, LINC00319 acts as a molecular sponge for miR‑4492, leading to the upregulation of ROMO1 and enhanced tumor aggressiveness"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and in cervical cancer, it drives cell migration, invasion, and epithelial–mesenchymal transition by modulating the miR‑3127‑5p/RPP25 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, in glioma, LINC00319 directly binds to TAF1 to regulate HMGA2 expression, thereby contributing to tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and in osteosarcoma, it enhances cell migration by affecting the miR‑455‑3p/NFIB pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Outside the realm of oncology, LINC00319 also aggravates neuronal injury in ischemic stroke by competitively binding to miR‑200a‑3p, which leads to increased apoptosis and reduced neuronal viability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted role of LINC00319 as a promoter of malignant progression and cellular injury, highlighting its potential as both a prognostic biomarker and a therapeutic target in diverse pathological contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenling Du, Zejiao Feng, Qinqin Sun "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00319 accelerates ovarian cancer progression through miR-423-5p/NACC1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.006"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30442370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30442370"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zeng-Wang Zhang, Jia-Jun Chen, Shi-Hui Xia, et al. 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