{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC00320 has emerged as an important regulatory molecule in the central nervous system with diverse roles in both cancer biology and normal brain function. In glioma, LINC00320 is notably down‐regulated in malignant tissues, and its reduced expression correlates with poor patient prognosis. Mechanistic studies have shown that nuclear LINC00320 exerts tumor‐suppressive effects by binding to β‑catenin and thereby disrupting the formation of the β‑catenin/TCF4 complex. This interference with the Wnt/β‑catenin signaling pathway ultimately hampers glioma cell proliferation; intriguingly, this process is regulated by HMGB1, forming a novel HMGB1/LINC00320/β‑catenin axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in malignant progression, LINC00320 has been identified as one of several immune‐related long non‐coding RNAs with prognostic value in low‐grade glioma, suggesting that it may also modulate the immune microenvironment of these tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Beyond oncogenesis, expression profiling in human brain tissues has revealed that the full‐length transcript of LINC00320 is exclusively expressed in brain white matter and appears to be absent in non‐human primates. This unique expression pattern implies a potential role in enhancing functional connectivity and higher cognitive processes in humans."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, coexpression analyses in breast cancer have associated LINC00320 with gene networks involved in transcriptional regulation and glycosphingolipid biosynthesis pathways, indicating that its functional repertoire may extend to other regulatory processes beyond the nervous system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these studies highlight LINC00320 as a multifaceted long non‐coding RNA whose dysregulation contributes to glioma progression, while its brain‐specific expression points to additional roles in human neural function. Further research will be essential to fully elucidate its molecular mechanisms across different tissue contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuaiwei Tian, Wei Liu, Yixin Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA Linc00320 inhibits glioma cell proliferation through restraining Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.101"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30503496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30503496"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Aierpati Maimaiti, Lei Jiang, Xixian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation of an individualized prognostic signature of lower-grade glioma based on nine immune related long non-coding RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Neurol Neurosurg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clineuro.2020.106464"}], "href": "https://doi.org/10.1016/j.clineuro.2020.106464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33454543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33454543"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "James D Mills, Jieqiong Chen, Woojin S Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-015-0445-1"}], "href": "https://doi.org/10.1007/s10048-015-0445-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25819921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25819921"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ying Dong, Ting Zhang, Xining Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of coexpressed long noncoding RNAs and genes in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Obstet Gynaecol Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jog.13840"}], "href": "https://doi.org/10.1111/jog.13840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30362198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30362198"}]}]}]}