{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00323 is a long non‐coding RNA that has emerged as a multifunctional regulator in several disease contexts. In breast cancer, for example, increased LINC00323 expression is part of a recurrence signature and is associated with poor clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cervical cancer, LINC00323 acts as a hub in a competing endogenous RNA network, where its dysregulation correlates with disease recurrence"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and similar associations with recurrence have been observed in osteosarcoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond oncology, LINC00323 contributes to inflammatory and vascular processes. In diabetic nephropathy, it has been shown to drive the polarization of M1 macrophages via the PI3K/AKT signaling pathway, thereby promoting renal inflammation and injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In the vascular system, LINC00323 is strongly induced under hypoxic conditions in endothelial cells, where it is essential for maintaining proper cell-cycle progression and capillary formation, indicating an important role in angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, its genomic localization within a Down syndrome candidate region for congenital heart defects suggests that LINC00323 may also influence cardiac development"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while emerging genetic studies have implicated LINC00323 as a candidate gene in essential tremor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC00323 participates in diverse biological processes—ranging from cancer recurrence and inflammation to angiogenic regulation and cardiac development—underscoring its potential as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hairong Liu, Juan Li, Pratirodh Koirala, et al. 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