{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Accumulating evidence in diverse human malignancies indicates that LINC00324 is a multifunctional long non‐coding RNA with context‐dependent roles in cancer. In several tumor types—including gastric cancer, osteosarcoma, hepatocellular carcinoma, colorectal cancer, non‐small cell lung cancer, nasopharyngeal carcinoma, papillary thyroid carcinoma, and ovarian teratocarcinoma—LINC00324 is found to be upregulated and functionally promotes cell proliferation, migration, invasion, and survival by acting as an oncogene."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": " Mechanistically, LINC00324 often acts as a competing endogenous RNA that sequesters microRNAs—including miR‑214‑3p, miR‑10b‑5p, miR‑139‑5p, miR‑3200‑5p, miR‑615‑5p, miR‑195‑5p, and miR‑3164—to derepress downstream oncogenic targets such as FAM83B, WDR66, TRIM29, IGF1R, BCAT1, Fas ligand, and PAD4."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In addition, LINC00324 enhances the stability of specific mRNAs through its interaction with RNA‐binding proteins such as HuR and PU.1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In contrast, in certain cancers such as breast cancer the downregulation of LINC00324 correlates with enhanced malignancy through modulation of epithelial markers via miR‑10b‑5p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, aberrant LINC00324 expression and methylation patterns have been linked to leukemogenesis and are incorporated into prognostic risk models in acute myeloid leukemia, thymoma, lung adenocarcinoma, and other tumor types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": " Overall, these studies underscore that LINC00324 plays a critical, multifaceted role in tumorigenesis by influencing gene expression through miRNA sponging and mRNA stabilization, making it a promising diagnostic and therapeutic biomarker in precision oncology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "18"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "19"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zigui Zou, Tianshi Ma, Xuezhi He, et al. 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