{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00337 is an oncogenic long noncoding RNA that has been implicated in the progression of multiple tumor types by modulating key cellular processes such as proliferation, cell cycle progression, migration, invasion, chemoresistance, and angiogenesis. In esophageal squamous cell carcinoma, LINC00337 recruits transcription factor E2F4 to promote TPX2 expression, which in turn enhances autophagy, cell viability, and chemoresistance to cisplatin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer, its overexpression accelerates tumor cell proliferation and paclitaxel resistance, partly through the regulation of M2-like tumor‐associated macrophages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In pancreatic ductal adenocarcinoma, LINC00337 acts as a coactivator by binding E2F1, thereby driving cell cycle progression and proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in another esophageal cancer study, LINC00337 impairs miR‐145–mediated suppression of FSCN1, further contributing to tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In colorectal cancer, LINC00337 overexpression promotes cell proliferation, migration, and invasion via activation of the MEK/ERK pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and it further facilitates tumor angiogenesis by recruiting DNMT1 to the CNN1 promoter, leading to epigenetic repression of this tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In lung adenocarcinoma, LINC00337 contributes to tumor growth and progression by modulating the miR‐1285-3p/YTHDF1 axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and it also appears in competitive endogenous RNA networks that regulate key cell cycle and immune-associated genes, such as CHEK1, PBK, KIF23, and SLC7A11, thereby impacting tumor immunity and patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In non‐small cell lung cancer, LINC00337 exerts its oncogenic function by epigenetically silencing TIMP2 via DNMT1 recruitment"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while in gastric cancer, it promotes cell proliferation by repressing the cyclin-dependent kinase inhibitor p21 through an EZH2-mediated mechanism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings indicate that LINC00337 contributes to tumorigenesis by interacting with transcription factors, microRNAs, and epigenetic regulators, thereby orchestrating a complex network that drives malignant phenotypes and therapeutic resistance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chengliang Yang, Sining Shen, Xiaoli Zheng, et al. 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