{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00348 is a long non‐coding RNA that has emerged as a candidate regulator in cancer. In cutaneous squamous cell carcinoma (cSCC), LINC00348 is co‐expressed with mRNAs such as ACY3, NR1D1, and MZB1, suggesting that it may play a role in modulating endoplasmic reticulum stress–induced apoptosis, autophagy, and ultimately cSCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, while a separate genome‐wide methylation profiling study in an Asian cohort of chronic lymphocytic leukemia (CLL) identified extensive differential methylation across various gene types—including numerous long non‐coding RNAs—the specific function of LINC00348 in this context remains to be fully elucidated. Nonetheless, its presence among epigenetically regulated non‐coding sequences underscores the broader significance of lncRNAs in tumorigenesis and cellular signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu Hu, Rong Li, Hongyin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of lncRNA-mRNAs co-expression network identifies potential lncRNA biomarkers in cutaneous squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-022-08481-0"}], "href": "https://doi.org/10.1186/s12864-022-08481-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35392800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35392800"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miyoung Kim, Eunyup Lee, Dae Young Zang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel genes exhibiting DNA methylation alterations in Korean patients with chronic lymphocytic leukaemia: a methyl-CpG-binding domain sequencing study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-57919-6"}], "href": "https://doi.org/10.1038/s41598-020-57919-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31974418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31974418"}]}]}]}