{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n An exome‐wide association study in a Japanese population investigating early‐onset coronary artery disease (CAD) identified several single nucleotide polymorphisms (SNPs) that were significantly associated with disease susceptibility. Among these findings, genetic variation within the long intergenic noncoding RNA gene LINC00354 emerged as being linked to CAD, suggesting that LINC00354 may have a regulatory role in pathways influencing cardiovascular risk. Although its precise molecular function remains to be fully delineated, the association implies that LINC00354 could modulate gene expression networks that contribute to the development of early‐onset CAD. These insights underscore the importance of further functional investigations to clarify how variations in LINC00354 may impact disease pathogenesis and to explore its potential as a biomarker or therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoshiji Yamada, Yoshiki Yasukochi, Kimihiko Kato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/br.2018.1152"}], "href": "https://doi.org/10.3892/br.2018.1152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30402224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30402224"}]}]}]}