{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00365 is a long non‐coding RNA whose function appears to be highly context‐dependent in cancer. In colorectal cancer, for example, studies have demonstrated that LINC00365 is upregulated and acts as an oncogene by sponging multiple microRNAs to regulate several messenger RNAs, thereby promoting cell proliferation, migration, and invasion via pathways such as Wnt/β‐catenin and by upregulating factors like CDK1 (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, investigations in gastric, breast, and lung adenocarcinoma have revealed that LINC00365 is frequently downregulated and appears to function as a tumor suppressor. In these contexts, restoration of LINC00365 expression has been shown to inhibit tumor cell growth, migration, invasion, and glycolysis, as well as to induce apoptosis through mechanisms involving targets such as SCGB2A1, inhibition of NF-κB signaling, and modulation of the miR-429/KCTD12 axis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, LINC00365 has been identified as a component of prognostic and diagnostic lncRNA signatures in esophageal and gastric cancers, where its expression correlates with critical clinical features such as lymph node metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that LINC00365 exerts divergent roles depending on the cancer type. In colorectal cancer, its oncogenic activity makes it a potential target for therapies aimed at disrupting its microRNA sponging functions, whereas in gastric, breast, and lung cancers, restoring LINC00365 expression or mimicking its downstream effects might offer therapeutic benefits. In addition, the inclusion of LINC00365 in multi-lncRNA prognostic models further underscores its potential as a clinically valuable biomarker in gastrointestinal malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yiping Zhu, Yinzhu Bian, Qun Zhang, et al. 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