{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00370 has been demonstrated to promote osteogenic differentiation of adipose‐derived stem cells (ADSCs) by functioning as a molecular sponge for miR-222-3p, thereby relieving the suppression of RGS4 expression. In this mechanism, upregulated LINC00370 results in increased RGS4 levels and enhanced activation of downstream signaling pathways, such as PI3K/Akt, which are critical for osteogenic differentiation. Moreover, in an ovariectomy-induced osteoporotic rat model, treatment with LINC00370 was shown to partially reverse osteoporosis-related bone loss and upregulate osteocalcin (OCN) expression, highlighting its potential protective role against osteoporosis. These observations suggest that targeting the LINC00370/miR-222-3p/RGS4 axis could be a promising strategy to enhance bone formation and counteract osteoporotic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lintao Li, Bing Zheng, Fan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Gerontol Geriatr (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.archger.2021.104505"}], "href": "https://doi.org/10.1016/j.archger.2021.104505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34450404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34450404"}]}]}]}