{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study investigating the role of non‐coding RNAs during osteogenic differentiation of human induced pluripotent stem cells (hiPSCs) from patients with cleidocranial dysplasia, LINC00379 was bioinformatically classified as an enhancer regulatory region (1). Its designation as an enhancer‐like ncRNA suggests that LINC00379 may participate in modulating the transcriptional landscape of key osteogenic genes, including RUNX2, thereby influencing osteoblast differentiation and bone formation. Although the study focused broadly on multiple ncRNAs, the identification of LINC00379 among enhancer regions highlights its potential involvement in the regulatory network that underpins osteogenesis."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Akio Ooki, Shoko Onodera, Akiko Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CAGE-seq analysis of osteoblast derived from cleidocranial dysplasia human induced pluripotent stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2020.115582"}], "href": "https://doi.org/10.1016/j.bone.2020.115582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32795676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32795676"}]}]}]}