{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in human cancers by acting as competing endogenous RNAs (ceRNAs) that sequester microRNAs and thereby regulate the expression of protein‐coding genes. In the context of muscle‐invasive bladder cancer, one such lncRNA – LINC00390 – has been identified as part of a dysregulated ceRNA network. This network, established through comprehensive expression profiling of patient samples, indicates that LINC00390 is aberrantly expressed and likely functions as a miRNA sponge to modulate the expression of target mRNAs involved in tumorigenesis and cancer progression. Furthermore, analyses have revealed its potential value as a prognostic biomarker and a candidate therapeutic target, providing new insights into the molecular mechanisms that underpin the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hanbo Wang, Leilei Niu, Shaobo Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of aberrantly expressed profiles of lncRNAs and miRNAs with associated ceRNA network in muscle-invasive bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13363"}], "href": "https://doi.org/10.18632/oncotarget.13363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27863388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27863388"}]}]}]}