{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent transcriptomic studies have identified LINC00393 as a long non‐coding RNA with context‐dependent roles in cancer. In cervical cancer, for instance, LINC00393 has been detected as a recurrent integration hotspot for human papillomavirus (HPV), suggesting that its genomic locus is susceptible to viral insertion events that may contribute to tumor development and serve as a marker of HPV‐associated cervical cancer subtypes and racial disparities in viral prevalence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer—particularly in the basal molecular subtype—LINC00393 is among a panel of enhancer‐related, H3K27ac‐dysregulated lncRNAs whose expression appears to be critical for cancer cell proliferation. Notably, pharmacological inhibition of CREBBP/EP300 bromodomains reduces H3K27 acetylation and downregulates LINC00393 expression, concomitantly curbing the growth of basal breast cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that LINC00393 may be mechanistically involved in tumorigenesis by acting as a site for viral integration in cervical cancer and by modulating epigenetically driven cell proliferation in breast cancer. Its dual implication as a potential biomarker and therapeutic target highlights the value of further functional investigations into its role across distinct cancer contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiongzi Qiu, Qing Zhou, Aoran Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of virus and host transcriptomes in cervical cancer in Asian and Western populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2021.03.029"}], "href": "https://doi.org/10.1016/j.ygeno.2021.03.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33785400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33785400"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hongying Zhao, Xiaoqin Liu, Lei Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive landscape of epigenetic-dysregulated lncRNAs reveals a profound role of enhancers in carcinogenesis in BC subtypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2020.12.024"}], "href": "https://doi.org/10.1016/j.omtn.2020.12.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33575113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33575113"}]}]}]}