{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study of early nutritional influences on child development, researchers investigated how exclusive breastfeeding impacts DNA methylation alterations during infancy, which in turn appear to mediate long‐term BMI trajectories."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " The genome‐wide analysis identified 13 CpG sites in girls and 2 in boys that serve as mediators of the association between exclusive breastfeeding and longitudinal BMI. Notably, one of these CpG sites is located within the region encompassing LINC00398 alongside ALOX5AP. Although the precise functional role of LINC00398 is not fully delineated within this study, its presence among the loci exhibiting methylation variation suggests that it may contribute to the regulatory network involved in metabolic pathways—such as those governing insulin signaling and energy homeostasis—that are crucial for mediating early growth trajectories and potentially mitigating the risk of later overweight or obesity. These findings underscore the critical impact of the early postnatal period, where even brief durations of exclusive breastfeeding (3 to 5 months) can instigate epigenetic modifications with lasting effects on child growth and metabolic health."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Laurent Briollais, Denis Rustand, Catherine Allard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation mediates the association between breastfeeding and early-life growth trajectories."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-021-01209-z"}], "href": "https://doi.org/10.1186/s13148-021-01209-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34937578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34937578"}]}]}]}