{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00400 is a long non‐coding RNA (lncRNA) that has recently emerged as an important player in colorectal cancer (CRC) through its role in regulating the competing endogenous RNA (ceRNA) network. In CRC, differential expression analyses have revealed that LINC00400 not only participates in the modulation of gene expression by sequestering microRNAs but also shows significant expression changes across multiple pathological stages. This dynamic expression pattern suggests that it helps govern key signaling pathways involved in tumor initiation and progression, underscoring its potential as a promising prognostic biomarker and therapeutic target for CRC. These findings contribute to the growing evidence that aberrant ceRNA networks, which include lncRNAs such as LINC00400, hold critical regulatory functions in colon tumorigenesis and disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fengxi Li, Qian Li, Xianghua Wu "}, {"type": "b", "children": [{"type": "t", "text": "Construction and analysis for differentially expressed long non-coding RNAs and MicroRNAs mediated competing endogenous RNA network in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0192494"}], "href": "https://doi.org/10.1371/journal.pone.0192494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29420609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29420609"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoxue Wang, Zhimin Liu, Hong Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc01194 acts as an oncogene in colorectal carcinoma and is associated with poor survival outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S189189"}], "href": "https://doi.org/10.2147/CMAR.S189189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30962722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30962722"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenliang Yuan, Xiaobo Li, Li Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of lncRNA-associated ceRNA network in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.151"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30503344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30503344"}]}]}]}