{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00402 is an emerging long non‐coding RNA that has recently been implicated in cancer progression through its role within competing endogenous RNA (ceRNA) networks. Notably, an integrative analysis of metastatic melanoma transcriptomes identified LINC00402 as one of several differentially expressed lncRNAs whose expression was significantly correlated with patient survival, suggesting a prognostic role and a potential involvement in modulating miRNA–mRNA interactions that impact tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, other studies have broadly characterized ceRNA networks in different disease contexts. For example, one study focused on colon cancer reported on the regulation of the tumor suppressor PHLPP2 by candidate lncRNAs and miRNAs, thereby highlighting the complex regulatory circuits in which lncRNAs operate, though LINC00402 was not specifically highlighted in that setting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in the context of immune responses post–hematopoietic stem cell transplantation, differential lncRNA expression patterns were associated with allogeneic T cell responses, indicating that lncRNAs play diverse roles in modulating immune function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In thyroid carcinoma, construction of a ceRNA network underscored the importance of lncRNA–miRNA–mRNA interactions in disease progression and patient prognosis, further emphasizing the potential for lncRNAs as biomarkers and therapeutic targets, although LINC00402 was not specifically noted in this system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies suggest that while lncRNAs broadly contribute to complex regulatory networks in various cancer and immune settings, LINC00402 in particular appears to be a promising candidate in metastatic melanoma where its expression is closely linked to clinical outcome. Further research is needed to define the mechanistic basis of LINC00402’s function and to explore its potential as a diagnostic or therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li-Xin Wang, Chuan Wan, Zheng-Bang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative Analysis of Long Noncoding RNA (lncRNA), microRNA (miRNA) and mRNA Expression and Construction of a Competing Endogenous RNA (ceRNA) Network in Metastatic Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.913881"}], "href": "https://doi.org/10.12659/MSM.913881"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31004080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31004080"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong-Kun Wu, Chang Liu, Xin-Xing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHLPP2 is regulated by competing endogenous RNA network in pathogenesis of colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103246"}], "href": "https://doi.org/10.18632/aging.103246"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32633726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32633726"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Daniel Peltier, Molly Radosevich, Visweswaran Ravikumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-seq of human T cells after hematopoietic stem cell transplantation identifies "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Linc00402"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as a regulator of T cell alloimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.aaz0316"}], "href": "https://doi.org/10.1126/scitranslmed.aaz0316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33731431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33731431"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yangjing Zhao, Hui Wang, Chengjiang Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and investigation of lncRNA-associated ceRNA regulatory network in papillary thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6207"}], "href": "https://doi.org/10.3892/or.2018.6207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29328463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29328463"}]}]}]}