{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent research has demonstrated that LINC00423 functions as a tumor suppressor in retroperitoneal liposarcoma by modulating key signaling pathways. Specifically, LINC00423 is downregulated in tumor tissues, and its overexpression leads to significant inhibition of cancer cell growth both in vitro and in vivo. Mechanistic studies revealed that LINC00423 destabilizes the protein nuclear factor of activated T-cells 3 (NFATC3) at the post‐transcriptional level, thereby negatively regulating the MAPK signaling pathway at the transcriptional level."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, advances in computational methods and sampling algorithms—including the Fisher's ratio, Holdout, and Random samplers—have enhanced the analysis of defective genetic pathways in complex cancer phenotypes such as triple negative breast cancer, highlighting the critical role of robust genomic analyses in understanding tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these studies underscore the importance of integrating functional lncRNA research with innovative genomic sampling techniques to elucidate the molecular underpinnings of cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yong Zhang, Hanxing Tong, Junyi He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc00423 as a tumor suppressor in retroperitoneal liposarcoma via activing MAPK signaling pathway through destabilizing of NFATC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1658-2"}], "href": "https://doi.org/10.1038/s41419-019-1658-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31160581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31160581"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ana Cernea, Juan Luis Fernández-Martínez, Enrique J deAndrés-Galiana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Robust pathway sampling in phenotype prediction. Application to triple negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Bioinformatics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12859-020-3356-6"}], "href": "https://doi.org/10.1186/s12859-020-3356-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32164540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32164540"}]}]}]}