{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00473 is markedly upregulated in glioma tissues and cellular models, where its increased expression correlates with poor patient prognosis. Functional studies have shown that knockdown of LINC00473 suppresses glioma cell proliferation, invasion, and migration, induces apoptosis, and leads to cell cycle arrest. In vivo, reduced expression of LINC00473 significantly impairs tumor growth. Mechanistically, LINC00473 acts as a competing endogenous RNA by sponging miR‑195‑5p, resulting in the derepression of downstream targets, including Yes‑associated protein 1 (YAP1) and TEA domain family member 1 (TEAD1), which are critical drivers of glioma progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xuan Wang, Xu Dong Li, Zhenyuan Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA LINC00473/miR‑195‑5p promotes glioma progression via YAP1‑TEAD1‑Hippo signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2019.4946"}], "href": "https://doi.org/10.3892/ijo.2019.4946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31894297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31894297"}]}]}]}