{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00443 is a long noncoding RNA implicated in the pathogenesis and progression of clear cell renal carcinoma (ccRCC)/kidney renal clear cell carcinoma (KIRC) through its role as part of competing endogenous RNA (ceRNA) networks. In these networks, LINC00443, along with other lncRNAs, miRNAs, and mRNAs, has been identified as a prognostic biomarker whose dysregulated expression is associated with patient survival and tumor stage. For instance, one study constructed a survival model using several lncRNAs—including LINC00443—demonstrating that these RNAs correlate with clinical prognosis in ccRCC patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Another study integrating LINC00443 into a three-lncRNA prognostic model for KIRC found that, unlike some of its counterparts which were upregulated, LINC00443 was significantly downregulated in tumor samples compared to adjacent normal tissues, suggesting it may function as a tumor suppressor or protective factor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In further analyses aimed at elucidating ceRNA regulatory relationships in ccRCC, LINC00443 was also identified among a set of lncRNAs significantly associated with overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Although one abstract provided (PMID: 30406146) did not include additional details regarding LINC00443, the collective findings support its involvement in RNA regulatory networks that could inform prognosis and therapeutic strategies in renal carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenjun Lu, Hengchen Liu, Xin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/8504441"}], "href": "https://doi.org/10.1155/2022/8504441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35529267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35529267"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Di Zhang, Song Zeng, Xiaopeng Hu "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a three-long noncoding RNA prognostic model involved competitive endogenous RNA in kidney renal clear cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01423-4"}], "href": "https://doi.org/10.1186/s12935-020-01423-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32694941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32694941"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiawu Wang, Chengyao Zhang, Weiyang He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and comprehensive analysis of dysregulated long non-coding RNA-associated competing endogenous RNA network in clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27557"}], "href": "https://doi.org/10.1002/jcb.27557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30278113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30278113"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kang Yang, Xiao-Fan Lu, Peng-Cheng Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Six Potentially Long Noncoding RNAs as Biomarkers Involved Competitive Endogenous RNA in Clear Cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2018/9303486"}], "href": "https://doi.org/10.1155/2018/9303486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30406146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30406146"}]}]}]}