{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a genome‐wide association study of African Americans with type 2 diabetes–associated end‐stage kidney disease, researchers expanded the discovery sample and imputed genotypes to a higher‐density reference panel to uncover genetic factors underlying diabetic kidney disease (1). Although the study identified six independent variants in or near protein‐coding genes—including RND3/RBM43, SLITRK3, ENPP7, GNG7, and APOL1—no direct association with LINC00448 was reported, nor was its role in renal pathology explicitly defined (1). LINC00448, a long intergenic noncoding RNA, is generally understood in the broader literature to be involved in the regulation of gene expression at transcriptional or epigenetic levels. Its potential influence in modulating pathways relevant to kidney function or injury remains an attractive hypothesis for future research, particularly in the context of complex diseases like diabetic kidney disease where regulatory RNA molecules may have critical—but as yet unelucidated—roles."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meijian Guan, Jacob M Keaton, Latchezar Dimitrov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-019-0205-7"}], "href": "https://doi.org/10.1186/s40246-019-0205-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31092297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31092297"}]}]}]}