{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations have examined the potential role of the long intergenic non‐coding RNA LINC00449 in cancer. An initial report described LINC00449 as a regulator of proliferation and invasion in acute monocytic leukemia; however, this study was subsequently retracted because of significant errors during figure compilation and the reuse of image elements in different scientific contexts, raising concerns about data reliability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, an independent RNA‐sequencing study of triple‐negative breast cancer (TNBC) tissues found that LINC00449 is expressed at significantly higher levels in tumor tissues compared with adjacent normal tissues. In this study, elevated LINC00449 expression was associated with both worse overall survival and reduced disease‐free survival among TNBC patients, suggesting its potential use as an unfavorable prognostic biomarker in this aggressive breast cancer subtype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Another abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "was also provided, although it did not contribute additional mechanistic details regarding LINC00449’s function. Collectively, these findings indicate that while earlier data regarding LINC00449 in leukemia require cautious interpretation due to methodological issues, evidence from the TNBC study supports a role for LINC00449 in tumor progression and patient prognosis. Further research is warranted to clarify its mechanistic contributions and assess its potential as a clinical biomarker across different cancer contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Unknown Authors "}, {"type": "b", "children": [{"type": "t", "text": "Retraction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.30715"}], "href": "https://doi.org/10.1002/jcp.30715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35297049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35297049"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jie Ping, Shuya Huang, Jie Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between lincRNA expression and overall survival for patients with triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-020-06021-6"}], "href": "https://doi.org/10.1007/s10549-020-06021-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33247368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33247368"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "ShuQiao Zhang, XinYu Li, ChunZhi Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.736766"}], "href": "https://doi.org/10.3389/fgene.2021.736766"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34819945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34819945"}]}]}]}