{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00452, a long non‐coding RNA, appears to play multifaceted roles across various disease contexts. In ovarian cancer, aberrant expression of LINC00452 is associated with enhanced tumorigenic properties, where its dysregulation promotes cell proliferation, migration, and colony formation, suggesting a contributory role in carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of thymoma-associated myasthenia gravis, LINC00452 is part of a competitive endogenous RNA network; here, the LINC00452/miR-204/CHST4 axis is implicated in the regulation of thymic regulatory T cells, highlighting its potential involvement in modulating immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, integrative multi-omics analyses in cervical cancer have identified LINC00452 as one of eight long non-coding RNAs whose copy number variations and differential expression are linked to pathways in tumor metabolism and immunity, correlating with a poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these studies suggest that LINC00452 may function as a key regulator in tumor progression and immune modulation across a spectrum of pathologies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Juan Yang, Wei-Gang Wang, Ke-Qiang Zhang "}, {"type": "b", "children": [{"type": "t", "text": "LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103758"}], "href": "https://doi.org/10.18632/aging.103758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33168781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33168781"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fuqiang Wang, Hanlu Zhang, Guanghao Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LINC00452/miR-204/CHST4 Axis Regulating Thymic Tregs Might Be Involved in the Progression of Thymoma-Associated Myasthenia Gravis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Neurol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fneur.2022.828970"}], "href": "https://doi.org/10.3389/fneur.2022.828970"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35432149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35432149"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qihang Zhong, Minzhen Lu, Wanqiong Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Eight-lncRNA signature of cervical cancer were identified by integrating DNA methylation, copy number variation and transcriptome data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-021-02705-9"}], "href": "https://doi.org/10.1186/s12967-021-02705-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33557879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33557879"}]}]}]}