{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long non‐coding RNA LINC00459 plays an important tumor‐suppressive role in melanoma. In particular, research demonstrated that LINC00459 is significantly downregulated in melanoma tissues and cell lines, and its restoration in vitro and in vivo inhibits both cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Mechanistically, LINC00459 functions as a competitive endogenous RNA by sponging miR‐218, thereby relieving the miR‐218 mediated suppression of the dickkopf-related protein 3 (DKK3) gene. The resulting upregulation of DKK3 is associated with reduced melanoma progression. This ceRNA network elucidates a novel pathway underlying melanoma pathogenesis and suggests that LINC00459 may serve as both a potential biomarker and a therapeutic target in the management of melanoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuhua Yang, Wenxian Xu, Zhuojun Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-55701-x"}], "href": "https://doi.org/10.1038/s41598-019-55701-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31844121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31844121"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuhua Yang, Wenxian Xu, Zhuojun Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Author Correction: LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-01245-y"}], "href": "https://doi.org/10.1038/s41598-021-01245-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34759328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34759328"}]}]}]}