{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00461 is a long non‐coding RNA that has emerged as a critical regulator in multiple human diseases, particularly in various cancers. In several independent studies, LINC00461 was found to be upregulated in malignancies such as multiple myeloma, hepatocellular carcinoma, breast cancer, non‐small cell lung cancer, rectal cancer, gastric cancer, glioma, head and neck squamous cell carcinoma, glioblastoma, and acute myeloid leukemia, where its high expression is typically associated with advanced stage, enhanced cell proliferation, migration, invasion, epithelial–mesenchymal transition (EMT), and even chemoresistance (1,2,3,4,5,6,8,13,14,15,11). Mechanistically, LINC00461 often acts as a competing endogenous RNA by sponging specific microRNAs – for instance, miR‑15a/16 in myeloma (1), miR‑411‑5p in glioma (2), miR‑149‑5p in hepatocellular carcinoma (3), miR‑30a‑5p in breast and osteoarthritic chondrocytes (4,9), miR‑593‑5p in rectal cancer (5), miR‑4478 in non‐small cell lung cancer (6), miR‑942 in renal cell carcinoma (7), miR‑216a in glioma (14) and miR‑195 in head and neck cancer (13). These interactions serve to de‐repress downstream targets – including genes such as BCL‑2, TOP2A, LRIG2, ITGB3, CCND1, E2F1, LSD1, ZEB2, AQP4, and others – that regulate critical pathways involved in cell cycle progression, survival, and motility (3,4,5,6,7,8,13,14,15)."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its oncogenic roles, LINC00461 has also been implicated in non‐malignant conditions. Genetic studies have associated alterations at the LINC00461 locus with neuropsychiatric traits and schizophrenia, highlighting a potential role in neurodevelopment and the modulation of hippocampal function (12,16). Furthermore, its expression in mesenchymal stromal cell–derived exosomes has been suggested to contribute to the tumor microenvironment by enhancing cancer cell proliferation (1).\n\n Collectively, these findings underscore that LINC00461 acts as a pivotal molecular sponge, interfacing with multiple microRNAs to fine‐tune gene expression networks that drive tumor progression, chemoresistance, and possibly neurodevelopmental processes. Its consistent upregulation in various cancers and linkage to adverse clinical features render LINC00461 a promising candidate for both diagnostic biomarker development and targeted therapeutic intervention (1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16).\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n "}, {"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "t", "text": "<br>."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mingyang Deng, Huan Yuan, Sufang Liu, et al. 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