{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00462 is a long noncoding RNA that appears to play multifaceted roles in human disease, particularly in various cancers and metabolic injuries. In non‐small cell lung cancer, reduced expression of a closely related transcript (reported as LINC00426 in one study) was associated with advanced clinical stage and worse prognosis, suggesting a potential tumor‐suppressive role in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in several other malignancies LINC00462 is upregulated and appears to function as an oncogene. For instance, in hepatocellular carcinoma, elevated levels of LINC00462 in tissue and exosomal RNA have been linked to enhanced tumor aggressiveness and poorer clinical outcomes, with mechanistic studies implicating its involvement in activating pathways such as PI3K/AKT"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in pancreatic cancer LINC00462 acts as a promoter of tumor progression. Experimental evidence shows that its overexpression enhances cell proliferation, migration, invasion, and epithelial–mesenchymal transition via a competing endogenous RNA mechanism involving miR‐665 and subsequent upregulation of TGFBR1 and TGFBR2, which activate the SMAD2/3 pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In support of these findings, LINC00462 has also been identified as part of prognostic and immune‐related lncRNA signatures in pancreatic cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, LINC00462 may contribute to nonmalignant pathologies. In a high glucose–induced model of diabetic nephropathy, its knockdown alleviated oxidative stress and apoptosis in renal tubular epithelial cells via enhanced AKT activation, pointing to a pathogenic role in metabolic injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, in the context of hematological malignancies such as multiple myeloma, increased levels of LINC00462 in circulating exRNA have been proposed as potential biomarkers for relapsed and refractory disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LINC00462 may function as a double‐edged sword depending on the disease context. While its downregulation correlates with poor outcome in NSCLC, its elevated expression in hepatocellular carcinoma, pancreatic cancer, and multiple myeloma is associated with enhanced tumor progression and aggressiveness. These findings underscore its potential as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenjun Du, Juan Sun, Jundong Gu, et al. 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