{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent research has demonstrated that LINC00473 is significantly upregulated in pancreatic cancer tissues and cell lines, correlating with larger tumor size, advanced tumor node metastasis stage, poorer differentiation, and increased rates of perineural and lymphatic invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional studies employing siRNA‐mediated knockdown of LINC00473 in PANC‑1 cells revealed that reducing its expression leads to marked inhibition of cell proliferation, invasion, and migration. Mechanistically, LINC00473 appears to promote pancreatic cancer progression by activating the cAMP signaling pathway, which in turn induces phosphorylation of β‑catenin. This signaling cascade not only fosters tumor aggressiveness but also is associated with a poorer prognosis in affected patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X-F Hao, Y-X Zhang, X-X Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00473 functions as an oncogene and predicts poor prognosis in pancreatic cancer via the cAMP/β-catenin axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202005_21317"}], "href": "https://doi.org/10.26355/eurrev_202005_21317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32495868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32495868"}]}]}]}