{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00466 is an oncogenic long noncoding RNA whose dysregulated expression has been reported in several cancer types. In lung adenocarcinoma, LINC00466 is highly expressed and promotes tumor progression by sponging miR‐144, which leads to the up‐regulation of HOXA10 and enhanced cell proliferation, invasion, migration, and reduced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In triple‐negative breast cancer, increased LINC00466 levels serve as a prognostic biomarker and its oncogenic role is mediated by acting as a sponge for miR‐539-5p, ultimately facilitating cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Additionally, in breast cancer, LINC00466 has been implicated in competing endogenous RNA (ceRNA) networks where it interacts with miR-204 to regulate downstream targets, further supporting its role as a tumor promoter and a potential prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " In glioma, two independent studies have identified that LINC00466 is upregulated and enhances malignancy by different mechanisms: one study reported that LINC00466 sponges miR-137 to up-regulate PPP1R14B, thereby promoting proliferation, metastasis, and resistance to temozolomide"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while another study demonstrated that LINC00466 is transcriptionally activated by YY1 and acts as a sponge for miR-508, leading to the modulation of CHEK1 and contributing to tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, in lung squamous cell carcinoma, LINC00466 has emerged within ceRNA networks as a potential biomarker that distinguishes smoking-related cases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings highlight that LINC00466 functions as a ceRNA in various malignancies by sequestering tumor-suppressive miRNAs, resulting in the up-regulation of oncogenic targets and promoting tumorigenic processes such as proliferation, invasion, metastasis, and chemoresistance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tiangang Ma, Yanbing Hu, Yingxue Guo, et al. 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