{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Numerous studies have demonstrated that the long intergenic non‐coding RNA LINC00472 is a multifunctional regulator whose expression is frequently down‐regulated in a wide variety of human cancers. In breast, lung, hepatocellular, colorectal, renal, oral, gastric, pancreatic, and triple‐negative breast cancers, reduced LINC00472 expression—often resulting from promoter hypermethylation—is associated with enhanced proliferation, migration, invasion, epithelial–mesenchymal transition, and poorer patient outcomes, whereas its restoration suppresses tumor cell growth, induces apoptosis, and improves sensitivity to chemotherapeutic agents."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n Mechanistically, LINC00472 acts as a competing endogenous RNA (ceRNA) that sequesters oncogenic microRNAs (such as miR‐455‐3p, miR‐141, and miR‐196b‑5p) and/or interacts with transcription factors (e.g., YBX1) and epigenetic modifiers to regulate downstream targets and signaling pathways critical for cell cycle progression, invasion, and apoptosis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its tumor‐suppressive role in malignant contexts, LINC00472 has been implicated in non‐cancer pathologies. For example, in cardiovascular and inflammatory conditions such as atrial fibrillation and sepsis‐induced organ injury, aberrant LINC00472 expression modulates ceRNA networks—affecting factors like miR‐24/JP2/RyR2 in atrial fibrillation and the miR‐335-3p/MAOA or miR‐373‑3p/TRIM8 axes in sepsis models—which contribute to dysregulated cell survival and inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": "\n Moreover, its altered expression in plasma has been explored as a potential diagnostic or staging biomarker in disorders such as primary biliary cholangitis, diabetic kidney disease, and pterygium."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, emerging evidence suggests that LINC00472 contributes to immune regulation—for instance, in Alzheimer’s disease—and plays important roles within broader ceRNA networks in lung adenocarcinoma and in kidney cancers, thereby offering potential prognostic value and novel insights into disease mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "21"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LINC00472 functions predominantly as a tumor suppressor by regulating key oncogenic signaling pathways and gene expression networks, and its aberrant expression not only serves as a prognostic and predictive biomarker in various cancers but also plays context‐dependent roles in cardiovascular, inflammatory, and immune‐related diseases. These multifaceted activities position LINC00472 as a promising diagnostic and therapeutic target across a range of pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi Shen, Dionyssios Katsaros, Lenora W M Loo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3287"}], "href": "https://doi.org/10.18632/oncotarget.3287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25865225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25865225"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiangying Deng, Wei Xiong, Xianjie Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00472 regulates cell stiffness and inhibits the migration and invasion of lung adenocarcinoma by binding to YBX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-03147-9"}], "href": "https://doi.org/10.1038/s41419-020-03147-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33144579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33144579"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yi Shen, Zhanwei Wang, Lenora W M Loo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-015-3632-8"}], "href": "https://doi.org/10.1007/s10549-015-3632-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26564482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26564482"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhanwei Wang, Dionyssios Katsaros, Nicoletta Biglia, et al. 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