{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated the long intergenic non‐coding RNA LINC00482 as a regulatory RNA with potential roles in multiple disease contexts. In a heart failure investigation, LINC00482 was identified as one of four hub lncRNAs within a condition‐specific lncRNA–miRNA–mRNA regulatory network, suggesting that it may modulate key signaling sub‐pathways such as those related to MAPK and chemokine signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In AFP‐negative hepatocellular carcinoma, LINC00482 was part of a competitive endogenous RNA (ceRNA) network where its expression, together with other lncRNAs, was significantly associated with overall patient survival, indicating its value as a diagnostic and prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In bladder cancer, LINC00482 was found to be highly expressed in both cancer tissues and cell lines. Its expression correlated with that of matrix metallopeptidase 15 (MMP15) and interactions with transcription factor FOXA1 were investigated, suggesting a role in promoting tumor progression through the regulation of extracellular matrix remodeling and invasion processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in an analysis of spondyloarthropathy/ankylosing spondylitis, LINC00482 emerged as one of several hub lncRNAs within a network of competitive regulatory interactions, which implies that it may contribute to inflammatory signaling pathways linked to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the precise mechanisms by which LINC00482 influences these diverse biological processes remain to be fully elucidated, current evidence indicates that it plays a role in modulating key pathways involved in cellular signaling, stress responses, and extracellular interactions across cardiovascular, hepatic, urological, and rheumatological disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dong-Mei Han "}, {"type": "b", "children": [{"type": "t", "text": "Sub-pathway based approach to systematically track candidate sub-pathway biomarkers for heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2019.7319"}], "href": "https://doi.org/10.3892/etm.2019.7319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30936989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30936989"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zijing Liu, Youwei Pu, Yixi Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of Potential Molecular Biomarkers for Diagnosis and Prognosis of AFP-Negative HCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gen Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJGM.S323868"}], "href": "https://doi.org/10.2147/IJGM.S323868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34408477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34408477"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yizhuo Wang, Liping Zhang, Na Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15 "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " FOXA1 in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202247"}], "href": "https://doi.org/10.18632/aging.202247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33323547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33323547"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ming Ding, Ting-Jin Guan, Chuan-Yin Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub‑pathway method."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9395"}], "href": "https://doi.org/10.3892/mmr.2018.9395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30132545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30132545"}]}]}]}