{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00483 is an oncogenic long noncoding RNA that is frequently upregulated in several cancer types and exerts its tumor‐promoting effects primarily by functioning as a competing endogenous RNA. In lung adenocarcinoma, for example, LINC00483 is elevated, and its silencing not only downregulates HOXA10 by releasing miR‑144 but also enhances radiosensitivity and reverses epithelial–mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, studies in lung adenocarcinoma and colorectal cancer have shown that LINC00483 sponges miR‑204‑3p, thereby modulating the expression of targets such as ETS1 or FMNL2 to promote cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cervical cancer, LINC00483 acts as a molecular sponge for miR‑508‑3p, resulting in the upregulation of RGS17 and contributing to enhanced cell proliferation, migration, invasion, and reduced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In breast cancer, its overexpression—regulated by binding to IGF2BP1—further promotes tumor cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, LINC00483 has been implicated in endometrial carcinoma, where ceRNA network analyses suggest that it may contribute to tumor progression by upregulating CCNB1 through competition with miR‑183."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In gastric cancer, two independent studies have revealed that LINC00483 promotes tumor growth and metastasis by sponging distinct microRNAs—for instance, modulating the miR‑490‑3p/MAPK1 axis as well as miR‑30a‑3p/SPAG9 signaling, which in turn activates MAPK signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pancreatic ductal adenocarcinoma, upregulated LINC00483 drives progression via the miR‑19a‑3p/TBK1/MAPK cascade, underscoring its role as a promoter of cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these studies indicate that LINC00483 contributes to tumorigenesis and aggressive clinical behavior across multiple cancer types by acting as a microRNA sponge, modulating key downstream effectors involved in cell growth, metastasis, and response to therapy.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qing-Shan Yang, Bin Li, Ge Xu, et al. 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