{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrative analyses across several cancer types suggest that the long non‑coding RNA LINC00484 functions as a competing endogenous RNA (ceRNA) that modulates tumor‐related regulatory networks. In colorectal cancer, comprehensive profiling of differentially expressed mRNAs, microRNAs, and lncRNAs led to the construction of an lncRNA‑associated ceRNA network in which key lncRNAs—potentially including LINC00484—were linked with overall survival and distinct clinical features, implicating them in the regulation of miRNA–mRNA crosstalk that drives tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in rectal adenocarcinoma, system‐wide analysis identified several cancer‑specific lncRNAs that likely act as ceRNAs to sequester microRNAs; LINC00484 is among the candidate transcripts whose aberrant expression correlates with patient prognosis and clinical parameters."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Evidence from investigations into triple‐negative breast cancer further supports a role for lncRNAs in oncogenic ceRNA networks by mitigating miRNA functions, thereby indirectly controlling the expression of mRNAs involved in key signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " More broadly, findings across these studies point to a conserved function of LINC00484 in mediating ceRNA interactions that influence cancer biology, suggesting its potential utility as a diagnostic and prognostic biomarker as well as a therapeutic target in diverse malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiaowei Fan, Bingrong Liu "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S158309"}], "href": "https://doi.org/10.2147/OTT.S158309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29760555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29760555"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhiyuan Zhang, Sen Wang, Dongjian Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6296"}], "href": "https://doi.org/10.3892/or.2018.6296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29512732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29512732"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Naijun Yuan, Guijuan Zhang, Fengjie Bie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of lncRNAs and miRNAs with coding RNAs associated with ceRNA crosstalk network in triple negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S149308"}], "href": "https://doi.org/10.2147/OTT.S149308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29276392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29276392"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yikang He, Yangfan Ye, Wei Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel lncRNA Panel Related to Ferroptosis, Tumor Progression, and Microenvironment is a Robust Prognostic Indicator for Glioma Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.788451"}], "href": "https://doi.org/10.3389/fcell.2021.788451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34950662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34950662"}]}]}]}