{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00486 is a long noncoding RNA that has been identified as one of several genes recurrently targeted by hepatitis B virus (HBV) integration events in intrahepatic cholangiocarcinoma (ICC). In the study of HBV-related ICC, integration of HBV‐DNA into the genome was frequently observed in several genes, including LINC00486, suggesting that disruption of this lncRNA may contribute to the molecular events driving tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the precise biological role of LINC00486 remains to be fully characterized, its recurrent targeting by HBV integration implies that it could be involved in regulatory pathways that, when perturbed, may promote cancer development. This finding is set against a backdrop of diverse genomic and epigenomic studies in other contexts – such as the delineation of specific mutational signatures in Chinese lung cancer patients"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", the profiling of chromatin accessibility and lentiviral integration in CAR‐T cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and genome‐wide association studies of skin color in Korean women"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "– that collectively underscore the importance of genomic alterations in disease pathogenesis. Further studies are needed to elucidate the functional consequences of HBV integration at the LINC00486 locus and its potential contribution to ICC oncogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mengge Li, Min Du, Hui Cong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of hepatitis B virus DNA integration patterns in intrahepatic cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/hepr.13580"}], "href": "https://doi.org/10.1111/hepr.13580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33037855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33037855"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cheng Wang, Rong Yin, Juncheng Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-04492-2"}], "href": "https://doi.org/10.1038/s41467-018-04492-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29799009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29799009"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenliang Wang, Maria Fasolino, Benjamin Cattau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1919259117"}], "href": "https://doi.org/10.1073/pnas.1919259117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32094195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32094195"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jung Yeon Seo, Seung Won You, Joong-Gon Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GWAS Identifies Multiple Genetic Loci for Skin Color in Korean Women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2021.08.440"}], "href": "https://doi.org/10.1016/j.jid.2021.08.440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34648798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34648798"}]}]}]}