{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00487 appears to function as a regulatory long noncoding RNA with potential roles in both immune dysregulation and tumor biology. In the context of primary Sjögren’s syndrome, its expression is markedly upregulated across all B‐cell subsets and is strongly induced by interferon‐α, with expression levels correlating with disease activity. This suggests that LINC00487 may participate in the aberrant activation or maintenance of B-cell phenotypes associated with autoimmune pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma without fibrosis, LINC00487 is included in a prognostic risk scoring system for recurrence-free survival, implicating it as a candidate biomarker for predicting patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in lung squamous cell carcinoma, elevated expression of LINC00487—as part of a panel of risk-associated long intergenic noncoding RNAs—serves to distinguish malignant from nonmalignant tissues and is associated with poor prognosis, indicating its potential utility as both a diagnostic and prognostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Inamo, Katsuya Suzuki, Masaru Takeshita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren's syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13075-020-02248-2"}], "href": "https://doi.org/10.1186/s13075-020-02248-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32571405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32571405"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiaxiang Ye, Siyao Wu, Shan Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Risk scoring based on expression of long non‑coding RNAs can effectively predict survival in hepatocellular carcinoma patients with or without fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7528"}], "href": "https://doi.org/10.3892/or.2020.7528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32323856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32323856"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jieqiong Liu, Yali Yao, Zheyu Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional profiling of long-intergenic noncoding RNAs in lung squamous cell carcinoma and its value in diagnosis and prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.994"}], "href": "https://doi.org/10.1002/mgg3.994"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31617686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31617686"}]}]}]}