{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00494 is a long non‐coding RNA that has recently emerged as a potential regulator in diverse disease and developmental contexts. In ovarian cancer, LINC00494 has been characterized as an oncogenic lncRNA that directly binds to and enhances the activity of NFκB1, leading to increased NFκB1 expression. Elevated NFκB1 in turn binds the promoter of the tumor‐suppressor gene FBXO32 and represses its transcription, thereby facilitating enhanced cell migration, invasion, and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another study focused on the development of osteonecrosis of the femoral head, LINC00494 was identified as one of several highly connected nodes within a competing endogenous RNA network. Although its precise mechanistic role in this context remains to be fully elucidated, its inclusion in the network suggests that LINC00494 may contribute to the regulation of genes involved in skeletal development and vascular formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, transcriptomic profiling of human germ cells during spermatogenesis revealed that LINC00494 is among a set of lncRNAs showing consistent differential expression across multiple studies, thus implicating it in the regulation of male germ cell development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yang Shu, He Zhang, Jinqiu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00494 Promotes Ovarian Cancer Development and Progression by Modulating NFκB1 and FBXO32."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.541410"}], "href": "https://doi.org/10.3389/fonc.2020.541410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33585183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33585183"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ning Han, Zengchun Li "}, {"type": "b", "children": [{"type": "t", "text": "Non-coding RNA Identification in Osteonecrosis of the Femoral Head Using Competitive Endogenous RNA Network Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Orthop Surg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/os.12834"}], "href": "https://doi.org/10.1111/os.12834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33749138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33749138"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Meghali Joshi, Singh Rajender "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-020-00660-6"}], "href": "https://doi.org/10.1186/s12958-020-00660-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33126901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33126901"}]}]}]}