{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study of expression quantitative trait loci (cis‐eQTLs) in post‐mortem human brain tissue, researchers screened schizophrenia and affective disorder–associated single nucleotide polymorphisms (SNPs) for effects on gene expression, and they identified 2,224 cis‐eQTLs influencing 40 genes – including 11 non‐coding RNAs such as LINC00499 (1). Although the functional mechanisms of LINC00499 were not dissected in detail in this work, its identification among the non‐coding RNAs regulated by disease‐associated SNPs indicates that it may have a regulatory role in modulating gene expression in a region‐specific manner within the brain. Consequently, LINC00499 is suggested to contribute to the transcriptional networks underlying the risk of schizophrenia and affective disorders, highlighting the potential impact of non‐coding RNAs in the pathogenesis of these complex psychiatric conditions (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Oneil G Bhalala, Artika P Nath, Michael Inouye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1007607"}], "href": "https://doi.org/10.1371/journal.pgen.1007607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30142156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30142156"}]}]}]}