{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00501, a long non‐coding RNA, has emerged as a multifaceted molecule implicated in several cancer types. Although large‐scale analyses of genomic variation have revealed diverse patterns of structural variants in human populations"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", subsequent studies have focused on elucidating the role of LINC00501 in tumor biology. In liver cancer, LINC00501 was identified as one of several prognostic lncRNAs whose expression levels contribute to predictive risk models for overall and recurrence‐free survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " In non‐small cell lung cancer, LINC00501 is highly expressed compared with normal tissues; functional experiments demonstrated that its knockdown suppresses cell proliferation and invasion while enhancing apoptosis. Mechanistic investigations revealed that LINC00501 may function as a competing endogenous RNA by sequestering miR‑129‑5p, which in turn regulates HMGB1 expression—a pathway that appears to promote tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In gastric cancer, upregulation of LINC00501 in tumor tissues has been observed, with its expression significantly associated with clinicopathological features such as sex and tumor grade, thereby underlining its potential as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these studies support an oncogenic role for LINC00501, both as a functional mediator involved in tumor progression—via ceRNA or related regulatory mechanisms—and as a clinically relevant biomarker for diagnostic and prognostic applications.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Peter H Sudmant, Swapan Mallick, Bradley J Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Global diversity, population stratification, and selection of human copy-number variation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aab3761"}], "href": "https://doi.org/10.1126/science.aab3761"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26249230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26249230"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Lou, Jun Li, Dong Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of five long noncoding RNAs expression as competing endogenous RNAs in regulating hepatoma carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2468"}], "href": "https://doi.org/10.1002/cam4.2468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31392826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31392826"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiaxiang Ye, Jinyan Zhang, Yufeng Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of a competing endogenous RNA network reveals key long noncoding RNAs as potential prognostic biomarkers for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28655"}], "href": "https://doi.org/10.1002/jcb.28655"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30989713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30989713"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuchen Hou, Zheng Yu, Nga Lei Tam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-related lncRNAs as predictors of HCC patient survival: a prognostic model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30018707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30018707"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ruo-Tian Wang, Yi Zhang, Shu-Yang Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00501 Inhibits the Growth and Metastasis of Lung Cancer by Mediating miR-129-5p/HMGB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S254735"}], "href": "https://doi.org/10.2147/OTT.S254735"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32801746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32801746"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuyou Jiang, Xianqin Zhang, Li Rong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of the gastric cancer long non-coding RNA-associated competing endogenous RNA network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2021.12717"}], "href": "https://doi.org/10.3892/ol.2021.12717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33907566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33907566"}]}]}]}