{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long Intergenic Non‐Coding RNA 00504 (LINC00504) is emerging as an oncogenic regulator in a variety of cancers by modulating tumor metabolism, cell proliferation, apoptosis, migration, and invasion. In ovarian cancer, LINC00504 is upregulated and promotes tumor progression and aerobic glycolysis through functioning as a molecular sponge for miR‐1244, thereby enhancing cell proliferation and suppressing apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colon cancer, increased LINC00504 levels enhance cell viability and migration and stimulate xenograft tumor growth by interacting with c‐Myc, which promotes chromatin recruitment and transactivation of metabolic genes involved in pathways such as glucose metabolism, the pentose phosphate pathway, and the tricarboxylic acid cycle."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In non‐small cell lung cancer (NSCLC), although LINC00504 expression is generally lower in tumor tissues than in adjacent normal tissues, relatively higher levels are strongly associated with advanced TNM stage, lymph node metastasis, and shorter overall survival"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", whereas in lung cancer cells its knockdown suppresses proliferation, migration, and invasion while promoting apoptosis via miR‐876-3p upregulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In breast cancer, LINC00504 is overexpressed, particularly within the luminal A subtype, and its elevated expression is linked to poor prognostic features. Transcription factor RFX5 directly activates LINC00504 expression, and the lncRNA subsequently functions as a competing endogenous RNA that sequesters miR‐140-5p, leading to increased VEGFA expression and promotion of cell proliferation, migration, invasion, and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifaceted role of LINC00504 in reprogramming metabolic pathways and driving tumor progression across multiple cancer types, thereby highlighting its potential as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ya Liu, Xiaocui He, Yuli Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00504 regulates the Warburg effect in ovarian cancer through inhibition of miR-1244."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-019-03647-z"}], "href": "https://doi.org/10.1007/s11010-019-03647-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31691157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31691157"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinfeng Feng, Jun Ma, Shaoqun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A noncoding RNA LINC00504 interacts with c-Myc to regulate tumor metabolism in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28733"}], "href": "https://doi.org/10.1002/jcb.28733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30998289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30998289"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "H-P Ma, L-X Wang, W Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of LINC00504 is associated with aggressive progression and poor prognosis in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202001_20047"}], "href": "https://doi.org/10.26355/eurrev_202001_20047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32016971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32016971"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhen Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Silencing LINC00504 inhibits cell proliferation, invasion as well as migration and promotes cell apoptosis in lung cancer cells via upregulating miR-876-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytotechnology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10616-020-00424-5"}], "href": "https://doi.org/10.1007/s10616-020-00424-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33033968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33033968"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tieying Hou, Long Ye, Shulin Wu "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of LINC00504 Inhibits the Proliferation and Invasion of Breast Cancer via the Downregulation of miR-140-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S294965"}], "href": "https://doi.org/10.2147/OTT.S294965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34239305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34239305"}]}]}]}