{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00507 is emerging as a multifaceted long intervening non‐coding RNA with potential implications in both Alzheimer’s disease (AD) pathogenesis and brain development. In AD models, increased expression of LINC00507 in the hippocampus and cerebral cortex has been shown to promote tau hyperphosphorylation by acting as a competing endogenous RNA (ceRNA). Specifically, LINC00507 sponges miR‑181c‑5p, thereby relieving its suppression of both microtubule‐associated protein tau (MAPT) and tau‑tubulin kinase‑1 (TTBK1); the resulting overexpression of these proteins activates the P25/P35/GSK3β signaling pathway, which is critical for tau hyperphosphorylation and AD pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the broader context of ceRNA networks implicated in AD, reviews focusing on long non‑coding RNAs highlight such regulatory loops as promising avenues for diagnostic and therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, independent transcriptomic analyses have identified LINC00507 as a cortex‑specific lincRNA in non‑human primates and humans with age‑dependent expression patterns, suggesting a role in higher primate brain development; intriguing computational evidence also raises the possibility that LINC00507 may encode a micropeptide."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Yan, Hua Yan, Ying Teng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3268"}], "href": "https://doi.org/10.1002/jgm.3268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32891070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32891070"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hani Sabaie, Nazanin Amirinejad, Mohammad Reza Asadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer's Disease: A Systematic Scoping Review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Aging Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnagi.2021.742242"}], "href": "https://doi.org/10.3389/fnagi.2021.742242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34899268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34899268"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "James D Mills, Melanie Ward, Bei Jun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00507 Is Specifically Expressed in the Primate Cortex and Has Age-Dependent Expression Patterns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-016-0745-4"}], "href": "https://doi.org/10.1007/s12031-016-0745-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27059230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27059230"}]}]}]}