{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐protein coding RNA 00514 (LINC00514) has emerged as an important oncogenic regulator in a wide range of cancers. In breast cancer, for example, LINC00514 is highly expressed and promotes tumor proliferation, invasion, and metastasis while enhancing M2 macrophage polarization via increased STAT3 phosphorylation and subsequent upregulation of Jagged1‐mediated Notch signaling, which stimulates cytokine secretion that further modulates the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pancreatic cancer, LINC00514 functions as a competing endogenous RNA (ceRNA) that sponges miR‑28‑5p to upregulate Rap1b, thereby driving cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, studies in papillary thyroid cancer have demonstrated that LINC00514 acts by sequestering miR‑204‑3p to elevate CDC23 expression, leading to enhanced tumor cell growth and metastatic behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, LINC00514 sponges miR‑378a‑5p, resulting in increased sphingosine kinase 1 (SPHK1) levels and subsequent activation of lipogenesis‐related pathways that support aggressive tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In gastric cancer, LINC00514 contributes to cell growth and epithelial–mesenchymal transition (EMT) by binding miR‑204‑3p and thereby enhancing KRAS oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Its oncogenic role is further evidenced in neuroendocrine prostate cancer, where elevated LINC00514 expression correlates with aggressive clinical features and may serve as a potential biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In osteosarcoma, transcription factor SP1‐induced upregulation of LINC00514 promotes tumorigenicity via sponging miR‑708, leading to increased cellular proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, elevated serum levels of LINC00514 have been associated with hepatitis B virus–related liver diseases, and its upregulation in cervical squamous cell carcinoma drives proliferation and invasion through the miR‑708‑5p/HOXB3 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, in triple‑negative breast cancer, LINC00514 fosters malignant behavior by sequestering miR‑6504‑5p and miR‑3139, which leads to the derepression of CCDC71L and further supports tumor growth and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that LINC00514 primarily acts as a ceRNA that modulates distinct oncogenic signaling pathways by interacting with various microRNAs. Its deregulated expression across multiple tumor types not only drives key aspects of tumor progression—including proliferation, invasion, metastasis, and alterations in the tumor microenvironment—but also suggests that LINC00514 may represent a promising diagnostic marker and therapeutic target in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sifeng Tao, Qiang Chen, Chen Lin, et al. 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