{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00515, a long non‐coding RNA, has been implicated in diverse biological processes that affect both cancer progression and non‐cancerous conditions. In high‐grade serous ovarian cancer, transcriptome analyses revealed reduced LINC00515 expression in cisplatin‐resistant cells, suggesting that under certain contexts LINC00515 may play a regulatory role in drug response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in melphalan‐resistant multiple myeloma cells, LINC00515 is markedly upregulated and functions as a competing endogenous RNA that directly inhibits miR‑140‑5p, leading to an increase in ATG14 expression. This consequently enhances autophagy and chemoresistance, highlighting an oncogenic role for LINC00515 in this disease setting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in the context of glioma the inclusion of LINC00515 in an immune gene‐related lncRNA risk model indicates that its expression is positively correlated with key immune checkpoint molecules such as PDL1 and TIM‑3. This association implies that LINC00515 might modulate the tumor immune microenvironment and serve as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, in oligohydramnios, upregulation of LINC00515 has been observed along with predicted regulatory interactions with genes involved in focal adhesion and cytokine receptor pathways. This finding points to a potential role for LINC00515 in modulating cellular processes relevant to fetal membrane function and pregnancy outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifaceted functions of LINC00515, ranging from the regulation of autophagy‐mediated chemoresistance to the modulation of immune landscapes and cell adhesion pathways. Its differential expression in various pathological contexts positions LINC00515 as a promising candidate biomarker and potential therapeutic target across multiple disease models.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhi-Guo Zheng, Hong Xu, Sha-Sha Suo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep26093"}], "href": "https://doi.org/10.1038/srep26093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27193186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27193186"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daifeng Lu, Chuandong Yang, Zhitao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of Linc00515 Inhibits Multiple Myeloma Autophagy and Chemoresistance by Upregulating miR-140-5p and Downregulating ATG14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000492690"}], "href": "https://doi.org/10.1159/000492690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30121664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30121664"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xinzhuang Wang, Ming Gao, Junyi Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Immune Gene-Related Five-lncRNA Signature for to Predict Glioma Prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.612037"}], "href": "https://doi.org/10.3389/fgene.2020.612037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33391355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33391355"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yu-Hua Ou, Yu-Kun Liu, Li-Qiong Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA and transcriptomic analysis of fetal membrane reveal potential targets involved in oligohydramnios."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-020-00792-z"}], "href": "https://doi.org/10.1186/s12920-020-00792-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32948205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32948205"}]}]}]}