{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study investigating the anticancer activity of ivermectin in ovarian cancer, an initial panel of 16 long noncoding RNAs was evaluated for their involvement in the ivermectin‐mediated lncRNA‐EIF4A3‐mRNA regulatory axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Among these, LINC00517 was included as a candidate molecule; however, subsequent analyses employing lasso regression to develop a prognostic signature identified only three lncRNAs—ZNRF3-AS1, SOS1-IT1, and LINC00565—as key predictors of overall survival. This finding indicates that although LINC00517 was initially considered for its potential role in modulating the response to ivermectin, it did not exhibit a significant prognostic impact or robust association with the EIF4A3-mediated pathways compared to the other lncRNAs in this study."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Na Li, Xianquan Zhan "}, {"type": "b", "children": [{"type": "t", "text": "Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EPMA J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13167-020-00209-y"}], "href": "https://doi.org/10.1007/s13167-020-00209-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32549918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32549918"}]}]}]}