{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00518 is a long intergenic non‐coding RNA that is frequently upregulated in a variety of tumors—including breast, melanoma, prostate, cervical, lung, and colorectal cancers—and functions predominantly as an oncogene by modulating multiple cancer hallmarks. In breast cancer, for example, LINC00518 contributes to chemoresistance by acting as a competing endogenous RNA (ceRNA) that sponges miR‐199a, thereby leading to the upregulation of the drug efflux transporter MRP1 and reduced sensitivity to several chemotherapeutic agents (↗."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In melanoma, increased LINC00518 levels promote cell growth, invasion, metastasis, and even radioresistance by sequestering miR‐204‐5p and miR‐33a‐3p, which in turn modulate targets such as AP1S2 and the HIF‐1α/lactate dehydrogenase A axis (↗."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " Similarly, in prostate cancer, LINC00518 impairs the function of miR‐216b‐5p, leading to the dysregulation of factors such as GATA6, which is associated with paclitaxel resistance (↗"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in cervical cancer it stimulates the activation of the JAK/STAT3 pathway and promotes epithelial–mesenchymal transition (EMT) to enhance proliferation and metastasis (↗."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In breast cancer progression, LINC00518 also promotes CDX2 methylation via activation of the Wnt signaling pathway, thereby driving tumor cell proliferation and reducing apoptosis (↗."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its functional roles in driving oncogenesis and drug resistance, LINC00518 serves as an important biomarker in noninvasive molecular diagnostics. Several studies have incorporated LINC00518 into gene expression assays—most notably in the pigmented lesion assay—which, in combination with PRAME, distinguishes melanoma from benign pigmented lesions with high sensitivity and specificity (↗."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in lung cancers—including non‐small cell lung cancer (NSCLC) and lung adenocarcinoma (LUAD)—LINC00518 is integrated within broader ceRNA regulatory networks where it modulates cell proliferation, migration, and invasion via interactions with microRNAs such as miR‐216b‐5p, miR‐335-3p, and others, contributing to aggressive tumor behavior and serving as a potential prognostic biomarker (↗."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "20"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, a single nucleotide polymorphism within LINC00518 has also been linked to modulating behavioral traits such as social disinhibition, indicating that its biological influence may extend beyond cancer (↗."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted oncogenic functions of LINC00518—mediated largely via its ceRNA activity—and highlight its promise as both a diagnostic marker and therapeutic target across multiple malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liang Chang, Zhuang Hu, Zhenyu Zhou, et al. 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