{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00519, a long intergenic non‑coding RNA, is emerging as an important regulator in the pathogenesis of lung squamous cell carcinoma (LUSC) and potentially other squamous cell malignancies. Elevated expression of LINC00519, which can be activated by H3K27 acetylation, is associated with poor clinical prognosis and aggressive tumor behavior—including enhanced cell proliferation, migration, invasion, and reduced apoptosis—in LUSC."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Mechanistically, LINC00519 functions as a competing endogenous RNA (ceRNA) by sponging tumor‐suppressive microRNAs (miR‑450b‑5p and miR‑515‑5p), which leads to the up‑regulation of the oncogene Yes1 associated transcriptional regulator (YAP1) and subsequent tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Its significance is further supported by studies that have identified LINC00519 as a prognostic biomarker in predictive models based on patient RNA‑sequencing data"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and by its inclusion among key long intergenic non‑coding RNAs with potential prognostic utility in head and neck squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings suggest that LINC00519 not only contributes to LUSC tumorigenesis via a ceRNA-mediated mechanism but also holds promise as a candidate biomarker and potential therapeutic target in the context of personalized cancer management.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Peng Ye, Xiayi Lv, Rusidanmu Aizemaiti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H3K27ac-activated LINC00519 promotes lung squamous cell carcinoma progression by targeting miR-450b-5p/miR-515-5p/YAP1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12797"}], "href": "https://doi.org/10.1111/cpr.12797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32297697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32297697"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoting Zhang, Yue Su, Xian Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of the Prognostic Value of Long Noncoding RNAs in Lung Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/9273628"}], "href": "https://doi.org/10.1155/2022/9273628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35069738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35069738"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yu-Zhen Yin, Shi-Hua Yao, Chun-Guang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic analysis using a bioinformatics strategy identifies SFTA1P and LINC00519 as potential prognostic biomarkers for lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33527016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33527016"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Joanna Kozłowska, Tomasz Kolenda, Paulina Poter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Intergenic Non-Coding RNAs in HNSCC: From \"Junk DNA\" to Important Prognostic Factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancers (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cancers13122949"}], "href": "https://doi.org/10.3390/cancers13122949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34204634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34204634"}]}]}]}